The ProteomeScoutAPI [publication] is a Python automatic programming interface for the ProteomeScout database downloads that allows for the easy interaction with post-translational modification information including proteins and their annotations. We used the database and API to test the hypothesis that mutations near sites of modifications are more likely to be involved in human disease (since they are more likely to affect the regulation and recognition of the modification). The results can be found in our iPythonNotebooks from the publication.
The motivation and features of the combined ProteomeScout and API are:
- Enable the easy analysis of the PTMome
- Allow for reproducible analyses
- Allow for easy re-analysis in the future for the new PTMome